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Medical Specialty:
Cardiovascular / Pulmonary
Sample Name: Immunohistochemical Study
Description: Specimen - Lung, left lower lobe resection. Sarcomatoid carcinoma with areas of pleomorphic/giant cell carcinoma and spindle cell carcinoma. The tumor closely approaches the pleural surface but does not invade the pleura.
(Medical Transcription Sample Report)
CLINICAL HISTORY: Patient is a 37-year-old female with a history of colectomy for adenoma. During her preop evaluation it was noted that she had a lesion on her chest x-ray. CT scan of the chest confirmed a left lower mass.
SPECIMEN: Lung, left lower lobe resection.
IMMUNOHISTOCHEMICAL STUDIES: Tumor cells show no reactivity with cytokeratin AE1/AE3. No significant reactivity with CAM5.2 and no reactivity with cytokeratin-20 are seen. Tumor cells show partial reactivity with cytokeratin-7. PAS with diastase demonstrates no convincing intracytoplasmic mucin. No neuroendocrine differentiation is demonstrated with synaptophysin and chromogranin stains. Tumor cells show cytoplasmic and nuclear reactivity with S100 antibody. No significant reactivity is demonstrated with melanoma marker HMB-45 or Melan-A. Tumor cell nuclei (spindle cell and pleomorphic/giant cell carcinoma components) show nuclear reactivity with thyroid transcription factor marker (TTF-1). The immunohistochemical studies are consistent with primary lung sarcomatoid carcinoma with pleomorphic/giant cell carcinoma and spindle cell carcinoma components.
FINAL DIAGNOSIS:
Histologic Tumor Type: Sarcomatoid carcinoma with areas of pleomorphic/giant cell carcinoma and spindle cell carcinoma.
Tumor Size: 2.7 x 2.0 x 1.4 cm.
Visceral Pleura Involvement: The tumor closely approaches the pleural surface but does not invade the pleura.
Margins: Bronchial resection margins and vascular margins are free of tumor.
Lymph Nodes: Metastatic sarcomatoid carcinoma into one of four hilar lymph nodes.
Pathologic Stage: pT1N1MX.
See More Samples on Cardiovascular / Pulmonary
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Aortic Valve Replacement
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Lightheaded & Dizziness
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Lung adenocarcinoma Path Report
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Mayoview
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Mediastinal Mass Resection
Mesothelioma - Consult
Mesothelioma - Pleural Biopsy
Metastasectomy & Bronchoscopy
Microlaryngoscopy
Mitral Valve Repair & Annuloplasty
MRI of Lung - Adenocarcinoma
Multilobar Pneumonia
Multiple Medical Problems - Discharge Summary
Multiple Stent Placements
Murmur & Bacteremia.
Myocardial Perfusion Imaging - 1
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Myocardial Perfusion Imaging - 3
Myoview Perfusion Scan
Non-Q-wave Myocardial Infarction
Nuclear Cardiac Stress Report
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Patent Ductus Arteriosus
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Peripheral Effusion - Consult
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Preop Cardiac Consult
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Pulmonary Function Test
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Pulmonary Medicine Clinic Followup
Pulmonary Valve Stenosis
Q-Fever Endocarditis
Radionuclide Stress Test
Reactive Airway Disease
Saphenous Vein - Ligation & Stripping
Selective Coronary Angiography & Angioplasty
Septal Defect Repair
Shiley Tracheostomy Tube Insertion
Shone complex
Shortness Of Breath - Progress Note
Sick Sinus Syndrome
Single Frontal View of Chest
SOAP - Lung Mass
SOAP - Shortness of Breath
Stenting
Stress Test Adenosine Myoview
Stress Test Bruce Protocol
Stress Test Dobutamine
Stress Test Dobutamine Myoview
Stress Test Dobutrex
Stress Test Graded Exercise Treadmill
Stress Test Thallium
Subclavian Central Venous Catheter Insertion
Subxiphoid Pericardial Window
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Subxiphoid Pericardiotomy
Supraclavicular Lymphadenopathy
Supraventricular Tachycardia - Consult
Tachypnea
Telemetry Monitoring
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Tessio Catheter Insertion
Thoracentesis
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Thoracoabdominal Aneurysm
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Thoracoscopy/Thoracotomy
Thoracotomy & Bronchoscopy
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Thoracotomy & Pleurectomy
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Thromboendarterectomy
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Toronto Porcine Valve Insertion
Tracheostomy
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Tracheostomy Change
Tracheostomy Tube Consult
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Transesophageal Echocardiogram - 5
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Transesophageal Echocardiography Probe
Transthoracic Echocardiography
Treadmill Test
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Trouble breathing
Ultrasound - Carotid - 1
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Urgent Cardiac Cath
Ventricular Ectopy - Consult
VVIR Permanent Pacemaker Insertion
Keywords: cardiovascular / pulmonary, cytokeratin-20, hmb-45, melanoma, spindle cell carcinoma, tumor cells, carcinoma, immunohistochemical, lung, cytokeratin, sarcomatoid, spindle, pleural, cell, tumor,